Host factors and their effects on innate immunity and lung inflammation and injury
Dr. Suratt received his BA from Amherst College in 1988, and his MD from Columbia University’s College of Physicians and Surgeons in 1993. He completed internship and residency in Internal Medicine at Massachusetts General Hospital in 1996, before pursuing fellowship training in Pulmonary and Critical Care Medicine at the University of Colorado Health Sciences Center in Denver. His research training was performed in the laboratories of Drs. Scott Worthen and Peter Henson, at National Jewish Medical and Research Center.
The focus of our research is the role of host factors including genetic polymorphisms and acquired conditions, such as obesity, in altering the pulmonary innate immune response. Recent work includes study of upstream noncoding SNPs in the csf-3 gene which expresses the neutrophil growth and release factor G-CSF, and how such SNPs may affect host response to lung infection and injury. Following our recent publications on the effects of obesity and hypercholesterolemia on neutrophil function in humans and mice, as well as the response to lung injury and infection, we are also examining the underlying mechanisms of of these effects on pulmonary innate immunity and the pathogenesis of ALI/ARDS.
JM Petty, CC Lenox, DJ Weiss, ME Poynter, BT Suratt, Crosstalk between CXCR4/SDF-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow. J Immunology 2009 Jan 1;182(1):604-12.
BT Suratt, MD Eisner, CS Calfee, JB Allard, LA Whittaker, DT Engelken, J Petty, T Trimarchi, L Gauthier, PE Parsons, and the NHLBI Acute Respiratory Distress Syndrome Network. Plasma G-CSF levels correlate with clinical outcomes in patients with acute lung injury. Crit Care Med 2009 Apr;37(4):1322-8.
AE Dixon, DM Raymond, BT Suratt, LM Bourassa, CG Irvin, Lower airway disease in asthmatics with and without rhinitis. Lung 2008 Nov-Dec;186(6):361-8.
JM Petty, V Sueblinvong, CC Lenox., CC Jones, GP Cosgrove, CC Cool, RR Rai, KK Brown, DJ Weiss, ME Poynter, BT Suratt Pulmonary Stromal Derived Factor-1 (SDF-1) expression and effect on neutrophil recruitment during acute lung injury. J Immunology 2007; 178:8148-57.
GB Allen, BT Suratt, L Rinaldi, JM Petty, JHT Bates. Choosing the frequency of deep inflation in mice: Balancing recruitment against ventilator-induced lung injury. Am J Physiol 2006; 291:L710-7
R Loi, T Beckett, KK Goncz, BT Suratt, DJ Weiss. Limited restoration of cystic fibrosis lung epithelium in vivo with adult marrow-derived cells. Am J Respir Crit Care Med 2006;173: 171-9.
T Beckett, R Loi, R Prenovitz, M Poynter, KK Goncz, BT Suratt, DJ Weiss. Acute Lung Injury with Endotoxin or NO(2) Does Not Enhance Development of Airway Epithelium from Bone Marrow. Mol Ther. 2005 Jul 15
* indicates equal contribution
NBL Fellowship in Basic Immunological Research, NJRMC/UCHSC (1999)
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