Cell & Molecular Biology Program Event
Ms. Jamie Meadows
Microbiology & Molecular Genetics
University of Vermont
P. aeruginosa metabolism and regulation of carnitine and its derivatives
Tuesday November 6th, 2012
Pseudomonas aeruginosa is a Gram negative bacterium that is an opportunistic pathogen capable of colonizing various surfaces, medical devices, and organ systems in humans. P. aeruginosa has a tremendous metabolic diversity encoded in its genome that allows it to adapt readily to various environments. Our lab specifically studies compounds present in the lung environment, such as lipids and quaternary amine compounds, that we term host-derived compounds. This seminar will focus specifically on the compounds carnitine and acylcarnitines, which are used by mammals for lipid metabolism and may be used by P. aeruginosa for nutrition during infection. Previous studies have should that P. aeruginosa can utilize carnitine but the utilization of acylcarnitines had not been studied. My dissertation studies have focused on i) identifying how acylcarnitines are catabolized, specifically the characterization of a short-chain acylcarnitine esterase, ii) how acylcarnitines are imported into the cell, and iii) the regulation of carnitine and acylcarnitine catabolism.