The Stumpff Lab

The Stumpff Lab

The Stumpff Lab uses advanced microscopy to investigate fundamental questions about the cell division process in a collegial, team-oriented environment.

Faculty Investigator: Jason Stumpff, PhD, Assistant Professor. Dr. Stumpff received his BS in Biology from Eckerd College. He then received his PhD from the University of Colorado, Boulder in Molecular, Cellular, and Developmental Biology before doing his postdoctoral training at the University of Washington with their Physiology and Biophysics department. He joined UVM’s faculty in 2011.


Haein Kim (left), Dr. Stumpff, and Cindy Fonseca on a recent lab trip.

Haein Kim (left), Dr. Stumpff, and Cindy Fonseca on a recent lab trip.

Members:
~Haein Kim (CMB Grad Student)
~Cindy Fonseca (Research Technician)
~Samantha Bissonette (Undergraduate Honors Thesis Student)
~Julia Torvi (Summer Undergraduate Research Student)
~Dana Messinger (Undergraduate Research Student)
~Cooper Pearson (Undergraduate Research Student)
~Sean Lenahan (Undergraduate Work Study Student)

Accepting rotation students: Yes


Major Research Projects: Our lab uses a combination of quantitative cell biology, biochemistry and biophysics to investigate the mechanisms that control the dynamics and function of the mitotic spindle during cell division. We are also exploring how spindle dysfunction contributes to human health disorders, such as trisomy syndromes and cancer. The main questions currently being investigated in the lab are:

  1. How do molecular motor proteins control the lengths of different subpopulations of mitotic spindle microtubules?
  2. What mechanisms mechanically regulate attachments between chromosomes and spindle microtubules?
  3. How does the spatial control of mitotic chromosome movements contribute to the accurate segregation of the genome and its 3D organization during interphase?
  4. How do the mitotic functions of the Shwachman Bodian Diamond syndrome protein impact bone marrow failure and leukemia predisposition in SDS patients?

Dr. Stumpff (left) and Haein Kim working in the lab.

Dr. Stumpff (left) and Haein Kim working in the lab.


Exciting News in the Stumpff Lab:
In August 2013, Haein Kim’s abstract on the role of Kif18A in primordial germ cell development was selected for a poster presentation at the Motile and Contractile systems Gordon Conference.

In the Spring of 2014, Sam Bissonette successfully defended her Honors Thesis on the mechanical control of chromosome biorientation during mitosis and had a paper accepted at the Journal of Cellular Physiology.

In May 2014, Cindy Fonseca won an award for the best poster presentation at the Boston Area Mitosis and Meiosis meeting, which was held at the Whitehead Institute.


In summer 2014, Julia Torvi was awarded a Robert and Marilyn Woodworth Prize to fund her research on kinetochore force dynamics.

Also in summer 2014, Haein Kim was accepted into a summer course through the Center for Physics in Living Cells at the University of Illinois.

In 2014, Jason was recognized with a Basil O’Connor Starter Scholar Award from the March of Dimes to investigate the mechanical control of mitotic chromosome biorientation.

Check out more labs from our Lab Spotlight Series here!

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