On August 23, 2012, Science Magazine published a paper by CMB Program Alumnus, Michael Previs, Ph.D., S. Beck Previs, J. Gulick, J. Robbins, and CMB Faculty Member, David Warshaw, Ph.D. titled “Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments.”

In this paper, they delve into the mystery of how mutations in the gene for cardiac myosin-binding protein C (cMyBP-C) may alter the function of the heart and can cause sudden death, as often observed in young athletes.

Read their article in Science Magazine to find out more about their studies and results in researching cMyBP-C using single molecule microscopy, mass spectrometry, and transgenic mouse models of human heart disease.

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