On Friday, June 29, 2012, Cellular Immunology accepted a paper by Naresha Saligrama, MVSc; Rajkumar Noubade, Ph.D.; Laure K Case, Ph.D.; Matthew E Poynter, Ph.D.; and Cory Teuscher, Ph.D., titled “H1R EXPRESSION BY CD11B+ CELLS IS NOT REQUIRED FOR SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS.”
Naresha Saligrama, speaking of their paper:
“Previously, we identified the histamine H1 receptor (Hrh1/H1R) as an autoimmune disease gene in experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis (MS).
Using classical genetic approach, we explored the cell specific effects of H1R in EAE susceptibility by re-expressing H1R in H1RKO T cells and endothelial cells. In the present paper, we demonstrate that transgenic re-expression of H1R in H1RKO-CD11b+ cells neither complements EAE susceptibility nor T cell cytokine responses. Results of the present study highlight the cell specific effects of H1R in EAE or MS pathogenesis.”
Mr. Saligrama is a current graduate student in the CMB program under the mentorship of Dr. Cory Teuscher and Dr. Noubade is a 2007 CMB graduate of Dr. Teuscher’s lab. Dr. Case is a 2008 graduate of the University of Chicago, currently a Post-Doc Associate in the Med-Immunobiolgy department, and Dr. Poynter and Dr. Teuscher are CMB faculty members in Medicine.
Congratulations to all on their recent paper’s acceptance!