Research and/or Creative Works
Research in the Ballif lab is primarily focused on elucidating molecular mechanisms of signal transduction with two major emphases: (A) genetically-defined signaling pathways regulating vertebrate brain development and (B) core signaling pathways regulating cell proliferation, growth and survival. In addition to biochemical and cell biological approaches, we employ mass spectrometry-based proteomics as a primary tool to identify and quantitatively monitor proteins, their modifications and their interactions with other proteins following acute signal administration or across developmental stages. We are also using zebrafish, drawing on the expertise of our sister lab headed by Alicia Ebert, as an organismal model system to study signaling pathways regulating development, particularly neuronal positioning.
A second focus of our work involves developing and applying proteomic methodology to advance diverse lines of biological inquiry, some of which have had little to no interface with proteomics. This makes these projects both exciting and challenging. These collaborative projects range from the identification of novel human blood group antigens; to the identification of host proteins that interact with arenavirus proteins; to targeted proteomic characterizations of wasps, pitcher plant ecosystems, ants, fruit flies, unicellular ciliates and parasitic protozoa.
Areas of Expertise and/or Research
Signal transduction, proteomics, neuroscience
- Ph.D. (2001) Harvard University, Department of Cell Biology, Harvard Medical School
- Postdoctoral Fellow (2001 - 2003) Division of Basic Sciences, Fred Hutchinson Cancer Research Center
- Postdoctoral Fellow (2003 - 2006) Department of Cell Biology, Harvard Medical School
- (802) 656-1389
Marsh Life Science Building, Rm 311
Wednesdays 9:30 - 11:30