Chem 258: Chemical Biology

Lectures
Mon/Wed/Fri 9:05 - 9:55am, Angell room B104

Course Structure
The course is an advanced class that discusses how our ability to manipulate molecules allows us to discover biological function. The first half of the class will teach the necessary elements of biochemistry and molecular biology. The second half of the class will be a discussion of several key papers in the field that represent the state of the art of this new area of science.

Office Hours
Feel free to drop by my office any time. If you need to see me at a specific time, please make an appointment.

Email Questions
I strongly recommend students to send questions by email. If the question is relevant, I can post the answers to the whole class. If you don't want your question in the public domain, please mark your email confidential. I'll usually respond the same day.

Recommended Text
Biochemistry, 3rd Edition by Garrett and Grisham

Lecture Notes
Skeleton notes are provided as pdf files. You can print these out before the lecture, and annotate them as you wish.

Lectures 1-3: DNA and RNA

Lectures 4-6: DNA Transcription

Lectures 7-9: RNA Translation

Lectures 10-12: Protein Structure

Lectures 12-17: Introduction to Molecular Cloning

Lectures 18-20: Synthetic Cell-surface Glycosides [refs 1 2 3 4]

Lectures 21-24: Green Fluorescent Protein

Lectures 25-28: Engineering Kinase Specificity

Lectures 30-34: A Bacterium with 21 Amino Acids