We are extending our expertise in plasma membrane calcium pumps (PMCAs) to mouse olfactory neurons. We have found 4 PMCAs in mouse olfactory neurons, and loss of PMCAs in knockout animals (courtesy of G. Shull) slows calcium clearance after stimulation.

The Vermont Genetics Network
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Selected Publications

For a complete list of publications click here

• S. Ponissery Saidu, SD. Weeraratne, M. Valentine, R. Delay and Judith L. Van Houten (2009) Role of Plasma Membrane Calcium ATPases in Calcium Clearance from Olfactory Sensory Neurons, Chemical Senses 2009; doi: 10.1093/chemse/bjp008.
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• Wade E. Bell, Robin R. Preston, Junji Yano and Judith L. Van Houten (2007) Genetic dissection of attractant-induced conductances in Paramecium, The Journal of Experimental Biology 210, 357-365. (.pdf)
  
  
• S. Dilhan Weeraratne, Megan Valentine, Matthew Cusick, Rona Delay and Judith L. Van Houten (2006) Plasma Membrane Calcium Pumps in Mouse Olfactory Sensory Neurons, Chemical Senses Advance Access published on July 19, 2006. doi:10.1093/chemse/bjl014. (.pdf)
  
  
• de Ondarza, J., Symington, S.B., Van Houten, J.L. and Clark, J. M. (2003) G-Protein Modulators Alter the Swimming Behavior and Calcium Influx of Paramecium tetraurelia, J. Euk. Microbiol.50: 349-355. (.pdf)
  
  
• Yano, J., Rakochy, V. and Van Houten, J.L. (2003) Studies of GPI anchored proteins in chemosensory signaling using antisense manipulation of the Paramecium PIG-A gene expression Euk. Cell 2: 1211-1219. (.pdf)
  
  
• Dessen, P., Zagulski, M., Gromadka, R., Plattner, H., Kissmehl, R., Meyer, B., Betermier, M., Schultz, J., Linder, J.U., Pearlman, R.E., Kung, C., Forney, J., Satir, B., Van Houten, J., Keller, A-M., Froissard, M., Sperling, L., Cohen, J. 2001. Paramecium genome survey: a pilot project. Trends in Genetics 17 306-308. (.pdf)
  
  
• Paquette, C.A., V. Rakochy, A. Bush, and J.L. Van Houten. 2001. GPI anchored proteins in Paramecium tetraurelia: Possible role in chemoresponse. J. Exp. Biol. 204: 2899-2910 (.pdf)
  
  
• Van Houten, J.L. 2000. Chemoreception in Microorganisms. In “Neurobiology of Taste and Smell.” Silver, Restrepo, Finger eds., Wiley, NY. Pg 11-40.
  
  
• Van Houten, J.L., Yang, W.Q. and Bergeron, A. 2000. Glutamate chemosensory signal transduction in Paramecium. J. Nutrition 130: 946S-949S. (.pdf)
  
  
• Symington, S., Zhang, A., Karstens, W., Van Houten, J.L., and Clark, J.M. 1999. Characterization of pyrethroid action on ciliary calcium channels in Paramecium tetraurelia. Pesticide Biochem. Physiol. 65: 181-193.
  
  
• Van Houten, J.L. 1998. Chemosensory Transduction in Paramecium. Eur. J. Protistol. 34: 301-307.
  
  
• Bell, W.E., W. Karstens, Y. Sun, and J.L. Van Houten. 1998. Biotin chemoresponse in Paramecium. J. Comp. Physiol. A. 183: 361-366. (.pdf)
  
  
• Fraga, D., Yano, J., Reed, M., Chuang, R., Bell, W.E., Van Houten, J.L. and Hinrichsen, R. 1998. Introducing Antisense Oligonucleotides into Paramecium via electroporation. J. Euk. Microbiol. 45: 582-588
  
  
• Davis, D., Fiekers, J., and J.L. Van Houten. 1998. Intracellular pH and chemoresponse to NH4 + Paramecium. Cell Motil. and the Cytoskeleton. 40: 107-118.
  
  
• Yang, W.Q., Braun, C., Plattner, H., Purvee, J., and J.L. Van Houten. 1997. Cyclic nucleotides in glutamate chemosensory signal transduction of Paramecium. J. Cell Science 110:2567-2572. (.pdf)
  
  
• Elwess, N.L., and J.L. Van Houten. 1997. Cloning and molecular analysis of the plasma membrane Ca2+ ATPase gene in P. tetraurelia. J. Euk. Microbiol. 44: 250-257.
  
  
• Schlichtherle, M., Roos, D. and Van Houten, J.L. (1996) Cloning and molecular analysis of the dihydrofolate reductase-thymidylate synthase gene in P.tetraurelia. Molec. and Gen. Genetics 250: 665-673.
  
  
• Yano, J., Fraga, D., Hinrichsen, R. and Van Houten, J.L. (1996) Effects of calmodulin antisense oligonucleotides on chemoresponse in Paramecium. Chem. Senses 21: 55-58. (.pdf)