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My interests center on chemoreception using Paramecium, a single-cell animal, as a model. These cells are like little swimming neurons and, like our neurons that detect odors or tastes, they respond to stimuli by membrane electrical changes.
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We are extending our expertise in plasma membrane calcium pumps (PMCAs) to mouse olfactory neurons. We have found 4 PMCAs in mouse olfactory neurons, and loss of PMCAs in knockout animals (courtesy of G. Shull) slows calcium clearance after stimulation.
The Vermont Genetics Network
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Selected Publications
For a complete list of publications click here

Top Left: Paramecium tetraurelia. Top Right: Intracellular electrode recordings from cells in control or stimulus solutions.
Bottom Left: A polyacrylamide gel of the cAMP receptor eluting from a cAMP affinity column (Lanes 2 and 3).
Bottom middle: An agarose gel of control DNA and Paramecium DNA (lane 7) sheared for insertion into cloning vectors.
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